A drive-by compromise is when an adversary gains access to a system through a user visiting a website over the normal course of browsing. With this technique, the user's web browser is targeted for exploitation.
Multiple ways of delivering exploit code to a browser exist, including:
- Malicious ads are paid for and served through legitimate ad providers.
- Built-in web application interfaces are leveraged for the insertion of any other kind of object that can be used to display web content or contain a script that executes on the visiting client (e.g. forum posts, comments, and other user controllable web content).
Often the website used by an adversary is one visited by a specific community, such as government, a particular industry, or region, where the goal is to compromise a specific user or set of users based on a shared interest. This kind of targeted attack is referred to a strategic web compromise or watering hole attack. There are several known examples of this occurring. 
Typical drive-by compromise process:
- A user visits a website that is used to host the adversary controlled content.
- Scripts automatically execute, typically searching versions of the browser and plugins for a potentially vulnerable version.
- The user may be required to assist in this process by enabling scripting or active website components and ignoring warning dialog boxes.
- Upon finding a vulnerable version, exploit code is delivered to the browser.
- If exploitation is successful, then it will give the adversary code execution on the user's system unless other protections are in place.
- In some cases a second visit to the website after the initial scan is required before exploit code is delivered.
Unlike Exploit Public-Facing Application, the focus of this technique is to exploit software on a client endpoint upon visiting a website. This will commonly give an adversary access to systems on the internal network instead of external systems that may be in a DMZ.
PLATINUM has sometimes used drive-by attacks against vulnerable browser plugins.
Drive-by compromise relies on there being a vulnerable piece of software on the client end systems. Use modern browsers with security features turned on. Ensure all browsers and plugins kept updated can help prevent the exploit phase of this technique.
Other types of virtualization and application microsegmentation may also mitigate the impact of client-side exploitation. The risks of additional exploits and weaknesses in implementation may still exist. 
Security applications that look for behavior used during exploitation such as Windows Defender Exploit Guard (WDEG) and the Enhanced Mitigation Experience Toolkit (EMET) can be used to mitigate some exploitation behavior.  Control flow integrity checking is another way to potentially identify and stop a software exploit from occurring.  Many of these protections depend on the architecture and target application binary for compatibility.
Firewalls and proxies can inspect URLs for potentially known-bad domains or parameters. They can also do reputation-based analytics on websites and their requested resources such as how old a domain is, who it's registered to, if it's on a known bad list, or how many other users have connected to it before.
Network intrusion detection systems, sometimes with SSL/TLS MITM inspection, can be used to look for known malicious scripts (recon, heap spray, and browser identification scripts have been frequently reused), common script obfuscation, and exploit code.
Detecting compromise based on the drive-by exploit from a legitimate website may be difficult. Also look for behavior on the endpoint system that might indicate successful compromise, such as abnormal behavior of browser processes. This could include suspicious files written to disk, evidence of Process Injection for attempts to hide execution, evidence of Discovery, or other unusual network traffic that may indicate additional tools transferred to the system.
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