Data Transfer Size Limits
An adversary may exfiltrate data in fixed size chunks instead of whole files or limit packet sizes below certain thresholds. This approach may be used to avoid triggering network data transfer threshold alerts.
Network intrusion detection and prevention systems that use network signatures to identify traffic for specific adversary command and control infrastructure and malware can be used to mitigate activity at the network level. Signatures are often for unique indicators within protocols and may be based on the specific obfuscation technique used by a particular adversary or tool, and will likely be different across various malware families and versions. Adversaries will likely change tool command and control signatures over time or construct protocols in such a way to avoid detection by common defensive tools. 
Analyze network data for uncommon data flows (e.g., a client sending significantly more data than it receives from a server). If a process maintains a long connection during which it consistently sends fixed size data packets or a process opens connections and sends fixed sized data packets at regular intervals, it may be performing an aggregate data transfer. Processes utilizing the network that do not normally have network communication or have never been seen before are suspicious. Analyze packet contents to detect communications that do not follow the expected protocol behavior for the port that is being used. 
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