Adversaries may use fallback or alternate communication channels if the primary channel is compromised or inaccessible in order to maintain reliable command and control and to avoid data transfer thresholds.
JHUHUGIT tests if it can reach its C2 server by first attempting a direct connection, and if it fails, obtaining proxy settings and sending the connection through a proxy, and finally injecting code into a running browser if the proxy method fails.
Mis-Type first attempts to use a Base64-encoded network protocol over a raw TCP socket for C2, and if that method fails, falls back to a secondary HTTP-based protocol to communicate to an alternate C2 server.
Network intrusion detection and prevention systems that use network signatures to identify traffic for specific adversary malware can be used to mitigate activity at the network level. Signatures are often for unique indicators within protocols and may be based on the specific protocol used by a particular adversary or tool, and will likely be different across various malware families and versions. Adversaries will likely change tool C2 signatures over time or construct protocols in such a way as to avoid detection by common defensive tools. 
Analyze network data for uncommon data flows (e.g., a client sending significantly more data than it receives from a server). Processes utilizing the network that do not normally have network communication or have never been seen before are suspicious. Analyze packet contents to detect communications that do not follow the expected protocol behavior for the port that is being used. 
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